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Paper Details


Title
Phytochemical investigation, cytotoxic and thrombolytic activity of acetone extracts of rhynchotechum ellipticum (Gesneriaceae)
Abstract
From the archaic timesRhynchotechum ellipticum(Gesneriaceae)usedlocallyas alleviates coughs in children. It is available in Chittagong and Sylhet, Bangladesh. The present study was carried out to investigate phytochemical, cytotoxic andthrombolyticactivity ofRhynchotechum ellipticumleaf and stem of acetonic extracts . The cytotoxic activity was determined by using brine shirmp lethality bioassayand thrombolytic activity was determined in accordance with clot disruption method. For cytotoxic activity, leaf and stem extracts showed LC 50 value 71.70 and 55 μg/ml; respectively. On the otherhand, the reference standard Vincristine sulphate showed LC 50 value was 2.63 μg/ml. In the thrombolytic activity of leaf and stemextracts showed clot lysis (41.98%) and (34.21%); respectively. The standard of Streptokinase showed clot lysis (68.42%).The extracts also showed moderate antibacterial activity.Itcan be revealed that the extract of Rhynchotechum ellipticum(Gesneriaceae)possesscytotoxicand thrombolytic activity. The potential of these activities may be due to the presence of most of the phytochemicals which supports previous claims and validate its uses as an expected folk medicine.
Keywords
Leaf, Stem, Streptokinase, Clot lysis, Cytotoxic activity, Vincristine sulphate
Authors
Md. Faysal, A.K. Azad, Fahadul Islam, Md. Mizanur Rahman, Md. Sarowar Hossain, Anwar Parvez, Md. Zamshed Alam Begh
Phone
Journal or Conference Name
Pharmacologyonline
Publish Year
2019
Indexing
Scopus