Metronidazole is a nitroimidazole derivative used for the treatment of antiprotozoal and bacterial diseases. It is one of the commonly produced and sold drugs of several pharmaceutical firms in Banglad esh. The physicochemical equivalence of five separate brands of metronidazole 400 mg tablets was calculated through examination of both official and non official USP pharmacopoeia specification, including weight uniformity, friability, strength, disintegration, dissolution and assay measures. Metronidazole tablets are film-coated tablets; all five Metronidazole brands tested comply with USP specifications for material standardization, weight variability, strength, friability, thickness, diameter, disintegration and dissolution. The sum of active metronidazole ranges between 97.0±0.43 and 101.50±0.25 percent of the goods. The average hardness of the items ranges from 12.5±0.77 kg/cm to 14.3±0.60 kg/cm, respectively. Metro-02 had the lowest mean friability test (0.06%) and Metro-03 had the height mean friability test (0.69%). All products had a disintegration time of 7.25±0.69 to 17.0+±0.63 minutes, with 85.34±0.21 to 98.87±0.38 percent release of active ingredient within 60 minutes of dissolution testing. This can confirm the absorption of the drug from the gastrointestinal tract for optimal therapeutic benefit. The present study revealed that all of the leading brands of this tablet met the quality control parameters as per pharmacopoeial specifications.