In this study, a new skin preservation method using Clerodendrum viscosum leaf has been explored to find out an efficient alternative to the most popular salted preservation in leather processing. The effectiveness of the preservation systems was evaluated on a regular interval by measuring parameters like organoleptic properties, moisture content, bacterial count, and hydrothermal stability of preserved skins. After preservation, the goatskins were processed into crust leather and compared with different strength properties of corresponding conventionally preserved skins. The cross-sectional fiber structure was found undamaged by assessing scanning electron microscopy images. The salt-free preservation method in this study could reduce the total dissolved solids and chloride in the soaking liquor by 74% and 98% respectively. In contrast, the less-salt preservation method could reduce the total dissolved solids and chloride by 57% and 59%respectively. The overall results of this study revealed that the leaf of Clerodendrum viscosum plant can be used to preserve skin. The strength properties of the produced leathers also fulfilled the requirements of shoe upper leather. The proposed Eco-friendly preservation techniques are found comparable to a great extent with the traditional salt curing approaches. So, these can be used as viable alternative options for skin preservation in the leather processing industries.