Objective: The present communication attempts to evaluate the Anti-inflammatory and Analgesic activities of ethanoic extract of Gynura Nepalensis (leaf) belongs to the family: Asteraceae, which is widely distributed in India. Methods: Ethanolic extract of Gynura Nepalensis (leaf) at doses of 250mg/kg and 500mg/kg were tested for their anti-inflammatory activity against Carrageenan induced paw edema & Xylene-Induced Ear Edema test in rats and analgesic activity was tested against Formalin-induced Paw licking test & acetic acid induced writhing (in mice) models and the two phases of formalin induced paw licking models of pain. Results: The results indicate that the ethanoic extracts at the doses of 250 and 500mg/kg body weight significantly inhibited, the carrageenan induced paw edema and Xylene-induced ear edema models of inflammation, similarly the extract at the doses of 250 and 500mg/kg significantly inhibited the acetic acid induced writhing (in mice) models and the two phases of formalin induced paw licking models of pain. Conclusion: This study confirms that the ethanoic extract of Gynura Nepalensis has good analgesic and anti-inflammatory property. Further studies are necessary to isolate the compounds from the ethanoic extract of Gynura Nepalensis responsible for the activity