Bioactivity assessment of a widely distributed mangrove plant: Barringtonia acutangula
One of the widely distributed mangrove plant Barringtonia acutangula(L) (Family: Lecythidaceae)has been used in folk medicine in the treatment oftuberculosis, skindisease, inflammation, hemorrhoids and diarrhea.The aim of the investigationwas to evaluate the phytochemical, antibacterial,antioxidant ,cytotoxic and anthelminticactivityof barkextractof Barringtonia acutangula(L).In order to investigate the antioxidant activity2,2-diphenyl-1-picryl-hydrazil (DPPH) free radical scavengingwasused. Antibacterial activity was evaluated by disc diffusionmethod. Cytotoxic activity was evaluated by brine shrimp lethality bioassay. Evaluation of anthelmintic activity was compared with reference standard piperazine citrate.Phytochemical analysis of the extract indicated the presence of gums, glycosides, alkaloids, and flavonoids. Extract showed DPPH scavengingactivity(53.80μg/mL) that was comparable to standard ascorbicacid (20.83μg/mL).In disc diffusion assay experimentalextract showed potent antibacterial activity.In the brine shrimp lethality bioassay the extract showed LC50 at 5.82μg/ml and LC90 at 80μg/ml.Extracts showed moderate anthelmintic activity in adose-dependent manner.