The knowledge of the natural radioactivity content of various radionuclides in the rocks plays an important role in the health physics because of the population’s exposure to the radiation. The study is devoted to assessing the specific activity and examining the radiation hazard indices of naturally occurring radionuclides 226Ra, 232Th, and 40K in rocks samples at different locations in Gabal Qatar II, Eastern Desert, Egypt. The activities were measured using a γ-ray spectrometer with a hyperpure germanium detector (HPGe). They ranged from 279 ± 50 to 196061 ± 19726, from 48 ± 13 to 23223 ± 2342, and from 17 ± 2 to 1358 ± 216 Bq kg–1 for 226Ra, 232Th, and 40K, respectively. The calculated hazard indices due to natural radionuclides were higher than the average national and world recommended values; therefore, the rocks pose health risks to the population of the area.