Soil liquefaction during earthquake is deemed to be responsible for the failure of many infrastructures. This research aimed to examine the effects of relative density and initial effective confining pressure on liquefaction resistance of selected saturated sands. Series of laboratory undrained cyclic triaxial tests were carried out on two different sands at different relative densities and effective confining pressures. Results of the cyclic triaxial tests revealed that Cyclic Stress Ratio (CSR) that serves as an index for liquefaction resistance, at relative densities of 30%, 50%, and 70% are 0.15, 0.21, and 0.24 respectively. An increase in relative density results in an increase in CSR thereby making the soil more resistant against liquefaction. For a constant relative density of 55%, an increase in initial effective confining pressure from 50 kPa to 100 kPa caused CSR to decrease from 0.30 to 0.12. It is clear that soils are more resistant against liquefaction at low effective confining stresses than at relatively higher effective confining stresses.