Hygroryza aristatais the significantly most important traditional medicinal plant practitioners all over the country since long years. Seeds are cooling and astringent to urinary tract; useful in biliousness. Bythe use of this plant only a few investigations was done like: anti-inflammatory and antioxidant. The purpose of the study is to determine the thrombolytic and analgesic activity of Hygroryza aristataextract. Phytochemical screening of the methanolic extract of whole plant of Hygroriza Aristataindicates the presence of alkaloids, carbohydrates, flavonoid, glycoside, and steroid.In thrombolytic assay, methanolic extract of the Hygroriza aristata leavesexhibited a promising effect compared standard drug Streptokinase. Here, the extract exhibited 63% (for 100 mg) clot lysis activity whereas; Streptokinase exhibited 82% (for 30,000 I.U). The analgesic activity of the methanolic leaf extract of Hygroriza aristatawas also observed by acetic acid induced writhing in mice. This writhing was markedly reduced with increase of the amount of extract at 250 mg/kg (63.1%) and 500 mg/kg (70.24%) respectively. Here, Diclifenac-Na 10 mg/kg (54.76%) was used as a standard drug. Thus, we can assume that, Hygroriza aristata plant have a promising effect of thrombolytic and analgesic activity that showed a ways of inventing new lead compound having such type of pharmacological effects respectively