This proposed structure depicts Photonic crystal fiber (PCF) including hexagonal-core for liquid sensitivity. The pretending result shows that the suggested H-PCF obtains the higher level of relative sensitivity using Finite-element-Method (FEM). At wavelength 1330 nm for liquid Ethanol (n = 1.354) having the high relative sensitivity of 76.78%; low confinement loss of 6.94 × 10⁻¹² dB/m and the effective area of 7.04 μm² are achieved under the Water (H₂O), Ethanol (C₂H₅OH) and Benzyne analytes (C₆H₅-X, X = H, OH, CH₃).