Monkeypox is a zoonotic orthopoxvirus that develops sickness in people comparable to smallpox but with a far lower fatality rate. Because it is indigenous to western and central Africa, and outbreaks in the Western Hemisphere have been linked to the exotic pet trade and international tourism, this virus is medically essential. The orthopoxvirus genus, which belongs to the Poxviridae family, also includes the camelpox virus, cowpox virus, vaccinia virus, and variola virus, in addition to the monkeypox virus. The World Health Organization identified the virus in the 1980s. At that time, it was already widely believed to be the most widespread orthopoxvirus in the human population since the elimination of smallpox. Since its eradication, the virus has been confirmed to be at the top of the list of infectious diseases caused by viruses with the potential to be endemic or pandemic; this includes orthopoxvirus, Crimean-Congo hemorrhagic fever, Ebola virus disease, Hendra virus infection, influenza, Lassa fever, Marburg virus disease, MERS-CoV, SARS-CoV, Nipah virus infection, smallpox, yellow fever, Zika virus disease These infections are on the rise all over the globe. They often manifest themselves with neurological symptoms. The monkeypox virus has reemerged as a serious international health risk because it poses new dangers and may spread easily across national boundaries. Due to these effects, the World Health Organization has issued a global health emergency declaration about hMPXV,¹ confirming the smallpox virus continues to harm the human population—loss of human population since smallpox eradication. The virus has been plaguing the human population since the eradication of smallpox.^2,3 The COVID-19 pandemic proved that infections with the ability to spread globally might cause damage to the neurological system.⁴ Neurological conditions range from those affecting the central nervous system (such as meningitis, encephalitis, intraparenchymal hemorrhage, and seizures) to those affecting the peripheral nervous system (such as sensorimotor neuropathy, sensorineural hearing loss, and ophthalmoplegia), and even from post-infectious conditions to congenital ones (fetal microcephaly). Although the neurological manifestations of certain illnesses, such as monkeypox virus (MPXV) infection, are not fully understood, there have been isolated instances of such manifestations.⁵ The virus in question was responsible for the loss of the human population, as stated by the confirmation. The local monkeypox habitat has limited resources as a solid initiative for clinical identification, diagnosis, and prevention of monkeypox. These regions include places like Africa and South America. These regions consist of the following: Studies conducted after determining what has been successfully eradicated have found the monkeypox epidemic.^6-8 Smallpox and monkeypox are clinically quite similar. Symptoms of both illnesses, a high temperature and the development of a rash, manifest simultaneously after an incubation period of around ten days. Most instances of smallpox were classified as conventional smallpox, in which the exanthem developed in a centrifugal pattern over many days (e.g., macules, papules, vesicles, pustules, scabs). Thirty percent of those who became sick from it ultimately passed away. The development of increasing skin lesions defined neither the early nor the late hemorrhagic forms of the illness, and the former was virtually always fatal. Although, during an epidemic in the United States in 2003, physicians saw blood inside a patient’s skin lesions, it is not widely believed that monkeypox causes hemorrhaging in humans. The fatality rate associated with monkeypox is substantially lower than that associated with smallpox (> 10%). Still, the symptoms are otherwise identical to those of either the classic or modified forms of smallpox. Lymphadenopathy, often associated with monkeypox but not smallpox has not been reported by physicians treating smallpox patients in the past.⁹ Nevertheless, routine vaccinations against smallpox have been discontinued, requiring further study as the animal’s immunity is relatively low. Also, basic environmental research is needed to understand better the species of animals involved in the virus’s transmission and maintenance and how can administer preventive strategies. This study is necessary for two reasons. First, to better understand the animal species involved in the information and care of the virus. This is essential for two different reasons. Initially, research is needed to understand better the species that play a role in the virus’s spread and maintenance. Both have to prove that they are capable of fulfilling this responsibility.^10-12