This paper examines the role of Intellectual Capital (IC) and its contribution to Business Sustainability (BS) among Large Manufacturing Firms (LMF) in Malaysia. It seeks to explain the relationship between them under turbulent market conditions. The study used the survey method to collect data from 203 large companies, and the hypotheses were tested using Partial-Least Squares-Structural Equation Modeling. Based on the findings, two dimensions of IC, namely Human capital (HC) and Structural Capital (SC), had a significant effect on business sustainability, but Relational Capital (RC) did not. Also results indicate that Market Turbulence (MT) moderates the relationship between two IC dimensions, HC and RC but not that between SC and BS. The study findings can be used as guidelines by CEOs of LMFs, policy makers and researchers to comprehend positive the influence of MT and IC on BS.