Melatonin is a commonly available compound in living creatures that takes part in a variety of biological, endocrinological, and biological conditions at the cell membrane, epithelial, and natural levels. Its ability to pass through the blood-brain barrier without any support is well known. Melatonin has already been identified and competent in a diverse range of foods varying from fungi to animals and plants over the past few years. In animal-based foods, fish and eggs get the maximum melatonin substance, so even though nuts get the greatest melatonin material in plant foods. Melatonin quantities in serum samples have been discovered to substantially boost within a week of ingesting melatonin-containing food products. Moreover, research suggests that melatonin seems to have countless biological properties, for example, antioxidant potential, neuroprotective role, anti-inflammatory characteristics, anti-ageing properties, potent anti-obese agent, immune boosting, cytotoxic effects, cardiometabolic protection, and anti-diabetic activities. Melatonin has been shown to feature both protective and therapeutic effects in a wide range of diseases, such as neurodegenerative disorders. Melatonin has an advantageous outcome on brain diseases, based on all of the effective results validated with experimental and preclinical studies. It could be that ‘Melatonin’ is the remedy we have been searching for.