Naproxen is an NSAID that works by blocking down the hormones responsible for inflammation as well as pain and usually prescribed for the treatment of pain and inflammation, specified for the conditions such as arthritis, tendinitis spondylitis, and ankylosing. The quality of pharmaceutical finished products is one of the foremost disquiets to pharmaceutical industries. This study was designed to compare and evaluate several in-Vitro quality parameters of four commercially available brands of naproxen 250 mg tablet in Bangladesh including weight variation test; thickness; hardness; disintegration time; potency; and dissolution test according to established USP specifications. All four samples from four different pharmaceuticals were compliant with USP specifications for weight variation test; hardness test; thickness test; and disintegration time. In case of potency test only sample 2 (87.80%) failed to meet the USP specifications. All the samples had dissolved more than 80% of their labelled claim within 45 minutes of the test where the dissolution profile of sample 2 was very close to the lower limit of USP specification. The findings reported in this study can assist the Drug Control Authority to get an idea about the quality status of the marketed Naproxen tablets in Bangladesh