Antibiotic resistance is getting global treat and also many diseases are associated with oxidative stress caused by free radicals. The present study evaluated the in vitro antioxidant and antibacterial activities of methanol extract of Crystella denatata. In vitro antioxidant activities of the plant extract were determined by DPPH scavenging method as compared with standard antioxidants. Extract showed significant radical scavenging activity as IC50.25.27 µg/ml comparable IC50 8.687 µg/ml of standard ascorbic acid. Mild antibacterial activities were comparable with standard drug, Kanamycin. The present study provides evidence that Crystella denatata prove to be potent natural antioxidants and could replace synthetic antioxidants. Plants can also be used against pathogenic bacterial strains.