A novel single material-based anti-resonant fiber is designed, investigated, and explored in this article with supports of up to 64 OAM modes over the 0.6 μm to 1.0 μm as operating wavelength. The other properties of the designed fiber including confinement loss (CL), OAM purity, effective refractive index differences (ERIDs), and dispersion variations provide the exceptional output. This fiber, the CL approximately varies between the 5.7031 × 10⁻⁵ dB/m to 9.2537 × 10⁻⁴ dB/m, the OAM purity is 97% to 99%, the ERIDs are higher than for all the modes, and the least dispersion variations is −8.838 ps/km-nm for the EH_1,1 mode. All the outstanding properties of the presented fiber are calculated using the FEM and the PML within the COMSOL Multiphysics simulator. Therefore, to the ideal of our knowledge, the proposed anti-resonant fiber is mostly applicable in the high-quality long-distance fiber communications system.