The goal of this research was to create a partial least square structural equation model (PLS-SEM) with a second-order structural model to investigate the interaction between research-based methodologies and relationship factors that significantly influence learning satisfaction among university students. The instruments used in this study were a simple random sampling technique for structural equation model (SEM) analysis, while a quantitative process of survey data collection was manipulated through SPSS and Smart-PLS. The presented study attempted to explore whether teachers’ strategies are linked with their students for the students’ learning satisfaction. Thus, it represents the demands and expectations of two statistically significant common phenomena: research-based components and relationship approach components. This set of teaching techniques encourages university students and enhances their learning satisfaction. Moreover, this study explored teaching strategies that influence factors having a directly significant influence on learning satisfaction at university level. Each factor measures the relationship’s construct, proven to be a second-order SEM reflective model that is statistically significant. Our study explored learning satisfaction as an integral part of teaching strategies, by first- and second-order structural equation modeling, supported by students’ expectations, and the study’s empirical results provide potential implications for learning satisfaction.