This study assess the efficiency and identify the factors causing responsible for school inefficiency of Barisal division in Bangladesh using stochastic frontier analysis. Multiple regression analysis was used to investigate the impact of teachers’ preference and use of ICT on their knowledge and motivated factors in teaching and learning. The determinants of factors affecting to secondary school efficiency were investigated by Tobit regression analysis. Through the likelihood-ratio test, Translog model was found an appropriate than Cobb-Douglas model. The number of students, the number of class rooms and teaching ability of the teachers had a positive and significant contribution to improve the efficiency. The ICT lab, teacher’s preference of ICT tools like multimedia projector used played a contributor role in increasing the school efficiency. The urban secondary schools performed better than the rural secondary schools. Barisal district was found comparatively better for urban secondary schools and Jhalokhati district was for rural secondary schools. Both medium and high level ICT teaching ability have positive and significant influence on the secondary school efficiency. Government should take necessary steps to improve the teaching and learning system in Barisal division by improving the teacher-student ratio, rural school and conventional teaching method in secondary school.