PVC (polyvinyl chloride) is a thermoplastic polymer used extensively in industrial applications. The potentiality of PVC lies in various parameters, such as high tensile strength, biodegradability, large surface area, chemical stability, low weight, durability, cost-effectiveness, and availability. However, the low thermal stability and brittleness of pure PVC limit its acceptance in widespread applications. Therefore, modifying PVC with metal oxides and carbon nanofillers could substantially improve thermal stability, mechanical strength, biocompatibility, surface area, conductivity, etc. Enhanced properties in modified PVC result from the chemical and physical interaction between polymer and functionalized nanofillers and the good dispersion capability of nanofillers on polymer matrix, which is attributed to the excellent performances of nanocomposites in diverse fields. This paper aims to present an overview of the characterization, preparation, and applications of blend nanocomposites of PVC, which would benefit future developments in this field.