Gastric cancer (GC) is a serious global health concern. GC is a form of cancer that advances through the stomach lining. Therefore, there is a requirement to explore novel preventive strategies for GC. A novel study indicated that plant-derived compounds have significant anticancer properties and may provide a novel therapeutic approach for GC. Recent research has highlighted the potential role of natural compounds, particularly phytocompounds, in preventing GC. Compounds, such as curcumin, resveratrol, and epigallocatechin gallate, have significant anticancer properties against GC. The primary purpose of this study was to investigate the preventive properties of the phytocompounds against GC. The experimental findings included both in vitro and in vivo studies, clinical trials, and epidemiological investigations, providing a comprehensive evaluation of the potential impact of compounds on GC prevention. This review also provides a detailed overview of the probable medicinal effects of phytocompounds on the avoidance and treatment of GC, considering their complex molecular mechanisms of action, bioavailability, and safety. This study provides new perspectives on the possible significance of compounds in GC treatment and emphasizes their promise as a cutting-edge approach.