Electro-periodic Magneto-hydrodynamics (EPMHD), activation energy, and non-linear radiation are pivotal elements in engineering and industry also contribute to advancements in fields like heat transfer, materials science, and chemical engineering. Through similarity transformation, governing partial differential equations simplify into ordinary differential equations. Precise computational solutions are derived using the Nachtsheim-Swigert shooting iteration method (NSSIM) and the reliable 6th-order Runge-Kutta integration algorithm (RKIA). The profiles of velocities, temperatures, concentrations, skin friction, heat and mass transfer rate are presented by graphically. The novel aspect of this research is that thermal performance is enhanced by non-linear radiation by around 2.28%, whereas linear radiation only produces a 0.28% improvement in thermal performance. Also the mass transfer rate experiences a decrease of about 25.76% with increasing chemical reactions in the presence of activation energy and a more substantial 62.22% reduction in its absence, notably showing a comparatively milder decline of 36.46% in the presence of activation energy than in its absence. Furthermore, this study yields three novel linear regression equations, skillfully derived from the numerical and graphical results. This research have practical applications in understanding and optimizing processes involving fluid dynamics, such as the behavior of certain materials or substances subjected to stretching or deformation.