The increasing depletion of reserves of natural resources has led to a growing worldwide focus on the exploitation of available waste in new domains. The presence of weedy plants is pervasive on a global scale and has detrimental effects on several aspects of the environment, agriculture, and people's health. Therefore, repurposing these Agri-weed plants for beneficial purposes would be a significant achievement. Furthermore, since raw materials constitute a substantial portion of manufacturing costs, using weeds as a feasible substitute for raw materials might potentially provide considerable advantages for manufacturers. In this study, an endeavor has been made to the utilization of agricultural waste “Urena Lobata”, for the purpose of paper production. In the interim, the utilization of Urena Lobata as an alternative and sustainable raw material for pulp and paper industry could potentially offer a beneficial approach to mitigation of deforestation. The effective production of handsheets with weights of 70 g/m2 and 80 g/m2 was achieved using Urena Lobata fiber, Bleached Urena Lobata Fiber, and hardwood kraft pulp. Mechanical characteristics of handsheet's were comprehensively examined by the bursting index, tensile strength, tear index, brightness percentage and scanning electron microscope for handsheet's morphology. The results show that the handsheets produced by Urena Lobata fiber exhibit a much lower brightness percentage, high tensile strength and bursting index. Alongside, handsheets by bleached Urena Lobata fiber indicate higher brightness percentage, satisfactory values for tensile strength, bursting index, and tear index. The prepared materials are suitable for a broad spectrum of prospective applications, encompassing newsprint, tissue paper, filtration paper as well as high-quality writing and printing paper.