The present investigation was set as a database study that estimated the bioaccumulation and potential human health risks of Uranium 238 (U-238) when consuming Leiognathus sp. and Portunus sanguinolentus from  thefrom the Madras Atomic Power Station (MAPS) zone, India.  In the study, two hypothetical scenarios were applied The study applied two hypothetical scenarios about the consumption of those fish and crab, to calculatinge the values of some important pollution and human risk assessment indices, such as eEnrichment factor, bBioaccumulation factor, eEstimated daily intake, dDaily intake of radioactivity, cCommitted effective dose, lLifetime cancer risk hHazard, and rRisk quotient.  The results showed that the study area has a moderate enrichment of U-238 (2< EF <5) duringat all seasons;, furthermore, Leiognathus  sp. Leiognathus sp.   and P. sanguinolentus are hyper-accumulators (BAF>10.0) from sSeawater. r.The finding of this study demonstrates that, in light of the hypothetical 1^st and 2^nd scenarios, the index values arewere below the limit set, hence there is no radiation/chemical risk from the consumption of Leiognathus  sp.  and P. sanguinolentus as a dominant diet from the study area.