A significant number of people, either seasonally or permanently, migrate from the Thar Desert in Pakistan each year due to droughts caused by climate change. This study aims to investigate the determinants and consequences of these migration decisions, examine the effectiveness of migration as a climate adaptation strategy, and identify challenges in adapting to these changes. Data were gathered from 400 migrated households in the Mithi sub-district. A mixed-method approach was used, combining qualitative and quantitative methods. The findings revealed that threats to the standard of living, including lack of food and clean drinking water, unemployment, and limited educational and medical opportunities, were the primary reasons for permanent and temporary migration from ancestral locations. Migration significantly impacted the origin and destination regions, with positive or negative effects. Specifically, migrants identified various consequences for both the origin and destination communities, including population decline (63%), changes in age structure, increased demand for housing, economic fluctuations (73%), alterations in healthcare services, and increased psychological stress (77%). The study also revealed that individuals who migrated from the Thar Desert experienced improved conditions compared to their previous location, such as diversification of income sources, increased job stability, access to clean water and food, reduced health risks, and overall improvements in their living conditions. However, the destination communities faced significant challenges due to widespread resource depletion and environmental deterioration. Migrants encountered barriers to developing resilient livelihoods in destination areas, including lack of proper knowledge and information, institutional and government issues, environmental and technological challenges, and social and cultural issues. The study highlights the urgent need for comprehensive policies and sustainable solutions to address the root causes of migration and support the resilience of vulnerable populations.