Sixty-eight samples representing the derived soils of the Um Shaddad parent granites (Eastern desert, Egypt) were examined for their natural radioactivity and hazards assessment. For data acquisition, a NaI detector was utilized for the gamma ray measurements and the Induced Coupled Plasma Spectrometry ICP-MS and the Induced Coupled Plasma Atomic Emission Spectrometry ICP‐AES for elemental concentration. The radionuclides activity concentration for the weathered soils varied from 6.02 ± 6.64 to 201.26 ± 45.47, 14.13 ± 3.26 to 151.57 ± 50 and 72.84 ± 28.81 to 1624.84 ± 563.72, relative to 39.15 ± 14.3 to 211.7 ± 28.3, 23.2 ± 5.09 to 103.8 ± 29.27 and 288.4 ± 108.7 to 2585.7 ± 883.8 in the parent rocks, representing uranium ²³⁵U, thorium ²³²Th and potassium ⁴⁰K, respectively. These values are relatively lower when compared to granites from other countries and much lower than the values reported by UNCEAR for the natural building stones. The hazard indices of radium equivalent activity (Raeq), internal and external hazards (Hin, Hex), indoor and outdoor absorbed gamma dose rate (AEDE), Gamma and Alpha Indices (Iγ and Iα) are within the acceptable limits. While the Absorbed Gamma Dose Rate (AGDR), Annual Gonadal Dose Equivalent (AGDE) and Excess Lifetime Cancer Risk (ELCR) are beyond the allowable range assigned by UNCEAR. Therefore, Um Shaddad granites and their derived soils do create radiological health hazard as building material and could not be used for industrial application as they pose substantial radiological concern on human health.