In a rapidly urbanizing tropical region such as Dhaka, Bangladesh, improving energy efficiency in office buildings while maintaining occupant comfort and well-being is a critical concern. The purpose of this research is to investigate a comprehensive strategy for optimizing dynamic façade performance by employing parametric design on an existing building façade and comparing the building performance in terms of improved daylighting and visual comfort. This research demonstrated simulation-based evaluation techniques in the tropical context of Dhaka to address an effective indoor environment. An administrative office block in Dhaka was chosen as the base case for the research at the outset. Parametric design in façades was introduced as a methodology using Rhino-Grasshopper 3D modeling to systematically explore various design iterations while considering multiple climatic variables and their interdependencies. This approach allowed for the integration of local climate data to inform the design process. To assess improved daylighting performance, the study utilized advanced building performance simulation tools, e.g., Ladybug and ClimateStudio. The simulation result showed the comparison of the point-in-time illuminance, daylight availability, annual glare and visual comfort of the base case and the optimized modified case that showed the influence of different design parameters on daylighting and visual comfort. By employing this strategy, architects and designers can make in-formed decisions to achieve sustainable and occupant-centric office building de-signs in tropical regions. The findings have the potential to benefit both the building industry and occupants by promoting environmentally responsible design.