The study explores uranium series disequilibrium in altered granites to evaluate uranium mineralization and its radiochronological implications. Disequilibrium occurs due to chemical fractionation and alpha-recoil mechanisms, affecting isotopic ratios (²³⁸U, ²³⁴U, ²³⁰Th, ²²⁶Ra) and resource assessment. Gamma-ray spectrometry indicated varied radioactivity ratios ²³⁴U/²³⁸U close to equilibrium (⁓1) and others deviating (0.85–1.08), revealing uranium mobilization and secondary mineralization processes. The ratios of ²³⁸U/²³⁵U (21.97–26.91) vs. 21.7 imply alteration processes. These findings provide insights into the geochemical history and uranium migration within granites, aiding uranium resources evaluation and exploration by interpreting migration history and disequilibrium’s role in deposit accuracy.