In recent years, there has been a noticeable rise in the prevalence of physical ailments, most notably hypothyroidism, a condition that has garnered substantial attention due to its substantial impact on a significant portion of the population. To gain a comprehensive understanding of the disease’s severity, distinguishing between standard and affected diagnostic reports is imperative. In this work, we suggest using algorithmic models to facilitate early identification and increase knowledge of possible health hazards linked to hypothyroidism. Our approach is straightforward and well-suited for the prediction of uncomplicated cases of hypothyroid illness in real-world scenarios. Our dataset, sourced from Kaggle, served as the foundation for our research, which involved the utilization of a variety of classifiers, including RF, LR, GB, KN, ABC, DT, GS, and ensemble techniques. The DT classifier proved to be the most accurate, with an astounding accuracy rate of 98.278%. The findings were quite successful. In addition, the accuracy of the Voting Classifier RDGL was 97.218%, while the Stacking Classifier RDAS demonstrated an accuracy of 97.483%. Our optimization efforts, which included hyperparameter tuning, further enhanced the performance of each classifier. Based on extensive experimentation and a review of contemporary research, our findings unequivocally endorse the Decision Tree (DT) boosting classifier as exceptionally proficient, demonstrating a remarkable accuracy rate of 98.278% in the precise prediction of hypothyroid disease.