Surgical site infections (SSIs) linger to be among the supreme severe concerns facing today's health care system, triggering significant morbidity and mortality for patients while aggregating the overall budget of health care delivery. According to the Centers for Disease Control and Prevention (CDC), SSI is defined as the infections that arise locally or in deeper underlying tissue spaces and organs at the surgery site within 30 days following surgery. This review will now delve into the etiology, prevention, and treatment of SSIs by discussing recommendations and statistics provided by the CDC.