The convergence of Blockchain and the Internet of Everything (IoE) is a paradigm shift in the evolution of interconnected systems. IoE is a unification of all aspects of people, processes, data, and devices into a single large network. In addition to these tremendous opportunities, it also poses challenges, especially where security, transparency, trust are concerned. These specific challenges are dealt with promisingly by Blockchain, which essentially is a decentralized and immutable ledger. This chapter elaborates on the interaction of Blockchain and IoE and how Blockchain technologies would influence the security, transparency, and trustworthiness of IoE ecosystems. Through their realistic applications such as supply chain management, smart cities, and healthcare, practical insights into these implementations within IoE systems are offered. The chapter also considers the technical and operational synergies and challenges of the integration as well as future prospects, which provide valuable insights into the transformative possibilities of merging these two technology paradigms