Esomeprazole is the S-isomer of omeprazole, used to treat gastro esophageal reflux disease (GERD). It is widely produced and marketed drug by many pharmaceutical companies in Bangladesh. The aim of the study is to compare the different physical parameters including hardness, friability, diameter, thickness, disintegration time, dissolution test and assay for quality evaluation and characterization of tablets of five different brands of Bangladeshi pharmaceutical company. The specified compendial method is followed for their evaluation test. Esomeprazole Mg tablets are enteric coated tablet, there is no disintegration for any brand occurred in 0.1N HCl after 2 hours and all tablets are disintegrated within 30 minutes in phosphate buffer (pH 6.8). Hardness ranges from 5.32 to 7.12 kg/cm2. Drug release after 2 hours in 0.1N HCl were varied from 2.55% to 4.47% which is less than 10% and in phosphate buffer (pH 6.8) the percentage of drug release are between 100.9% and 102.4% after 60 minutes. In case of assay theresults of all brands are between 95.28% and 99.40%. The obtained results of all parameters are complied with pharmacopoeial limit. So from this study we can conclude that products of esomeprazole available in Bangladeshi pharmaceutical market meet the quality parameter to satisfy therapeutic efficacy.