This paper presents the effects on cotton fabric dyeing process (isothermal and migration) with reactive dyes. cottonfabric was dyed with reactive dyes with a analysis optimizing procedure by varying dyeing process (isothermal and migra-tion) and parameters. Dyes and chemicals are used for dyeing to achieve the appropriate effect. It was observed that dyeingprocess and parameters are wide-ranging for using different types of reactive dyes and auxiliaries. It helps to find out thedifferentiation between the two processes and provide a better result.