This paper presents the various effects on cotton fabric dyeing with reactive dyes. Most of the knitted cotton fabric was dyed with reactive dyes with a view of optimizing dyeing procedure of cotton fabrics by varying dyeing process and parameters. Three types of dyes are used for achieving the proper effect. It was observed that dyeing process and parameters are wide-ranging for using different types of reactive dyes and auxiliaries. It helps to find out the demarcation between the process and give a better solution.